Fig. 7
From: High-fat diet-induced osteoporosis in mice under hypoxic conditions
Effects of a HFD on gut metabolism in mice under hypoxic conditions, with Spearman correlation analysis and network visualization. (n = 6). Note: (A) PCA; (B) volcano plots; (C) enriched KEGG pathways; (D) differentially expressed metabolites; (E) Correlation analysis between the gut microbiota and metabolites; (F) correlation between gut metabolites and body and bone morphological indices; (G) correlation analysis between gut metabolites and HIF, as well as indices of gut injury; (H) correlation analysis between gut metabolites and bone metabolism indices; (I) correlation analysis between gut metabolites and cytokines; (J) correlation network diagram. In Fig. 7J, the node size reflects the connectivity of each substance, defined as the number of other substances that are significantly correlated with it. Higher connectivity is represented by larger node sizes. Additionally, the thickness of the lines between nodes represents the absolute value of the correlation coefficient; a thicker line indicates a stronger correlation